منابع مشابه
Derivatisable Cyanobactin Analogues: A Semisynthetic Approach
Many natural cyclic peptides have potent and potentially useful biological activities. Their use as therapeutic starting points is often limited by the quantities available, the lack of known biological targets and the practical limits on diversification to fine-tune their properties. We report the use of enzymes from the cyanobactin family to heterocyclise and macrocyclise chemically synthesis...
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Demethoxycurcumin, isolated from the rhizomes of Curcuma longa, was found to possess antitubercular activity against Mycobacterium tuberculosis H (37)Rv strain at 200 microg/mL. Derivatisation of this active principle yielded a potent agent 6, exhibiting considerable activity with a minimum inhibitory concentration (MIC) value of 7.8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strai...
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N Engl J Med 2005;352:174-83. Copyright © 2005 Massachusetts Medical Society. he discovery of insulin more than 80 years ago is considered one of the greatest medical breakthroughs of the 20th century. 1 The first commercial insulin preparations contained numerous impurities and varied in potency from lot to lot by as much as 25 percent. Manufacturing techniques improved rapidly, however, which...
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Different kinds of insulin analogues, both short acting as well as long acting, are now available which offer several benefits over human insulins including improved physiologic profile, greater convenience, reduced risk of hypoglycemia and, in some instances, less weight gain. Combined, these elements may increase a patient’s adherence to treatment, potentially increasing the level of glycemic...
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An insulin analogue is an insulin molecule whose composition has been altered in order to yield some advantage over standard human insulin, while retaining its biological effect. In the 1990s, insulin lispro (Humalog) was the first analogue to be licensed in the UK. Insulin glulisine is the latest. People with type 1 diabetes have no endogenous insulin secretory capacity and, require insulin th...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1971
ISSN: 0306-3283
DOI: 10.1042/bj1250051p